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An additional 15 trials were excluded because additional review demonstrated that they were either retrospective studies (2); incompletely randomized (1); used a symptom list during post-treatment assessments that did not include commonly reported symptoms of the disease (7) or had a non-completion rate of 20% or higher (5).
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Complaints about taste (which may impair compliance) occurred in 5% of pediatric patients.
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When only serum creatinine is available, the following formula 4 (based on sex, weight, and age of the patient) may be used to convert this value into creatinine clearance.
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